Similar frequencies of renin gene restriction fragment length polymorphisms in hypertensive and normotensive subjects.

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Similar frequencies of renin gene restriction fragment length polymorphisms in hypertensive and normotensive subjects.

A prospective study was conducted to compare the frequency of renin gene polymorphisms in normotensive and hypertensive subjects. Hypertensive (n = 102, blood pressure 168 +/- 17/103 +/- 9 mm Hg) and normotensive (n = 120, blood pressure 122 +/- 10/75 +/- 9 mm Hg) subjects were white, had similar age and sex distributions (hypertensive group, 45 +/- 10 years old and 52% female; normotensive gro...

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A lack of genetic linkage of renin gene restriction fragment length polymorphisms with human hypertension.

Because renin is an important enzyme in blood pressure regulation, we studied the possibility that an alteration in the structure of the human renin gene is genetically linked to human essential hypertension or associated with levels of plasma renin activity or blood pressure. By using specific DNA probes, we have identified four polymorphisms in the human renin gene with the restriction enzyme...

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ژورنال

عنوان ژورنال: Hypertension

سال: 1990

ISSN: 0194-911X,1524-4563

DOI: 10.1161/01.hyp.16.6.712